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Similarly, increased hyperphosphorylation of NS5A correlates with lower replication levels 42,63,64 and decreased interaction between NS5A and a cellular factor, human vesicle-associated membrane-protein associated protein A (hVAP-A) 63

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Last Published 05.01.2026 Effective Date: 05.01.2026 This policy addresses the use of Ketalar (ketamine) for anesthesia purposes and Spravato (esketamine) for the treatment of treatment-resistant depression (TRD) and major depressive disorder (MDD)